Offer

We support your projects with customized support, scientific and technical advice and high-value added services throughout the value chain of the development of therapeutic and prophylactic microbiome-based or drug candidates targeting infectious diseases.

Cynbiome® offers an innovative set of solutions to unlock the potential of drugs, vaccines candidates and human microbiome-based products targeting infectious diseases.

A one-stop-shop to support the preclinical development of your pipeline and move faster towards clinic.

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Patient samples, biospecimens, Bacterial isolates

Services & R&D
R&D programs only
R&D programs only
R&D programs only
Services & R&D
Strain Identification (aerobic, anaerobic or GMO strains), targeted isolation

Services & R&D
Services & R&D
Strain biobank

Services & R&D
R&D programs only
Strain Characterization

● Genotyping, phenotyping
Services & R&D
R&D programs only
● Resistance and biochemical profiling
Services & R&D
● Metagenomic, Whole genome sequencing (WGS)
Services & R&D
Services & R&D
● Computational analyses
Services & R&D
Services & R&D
R&D programs only
Sorting & cultivation of microorganisms in controlled atmosphere

Services & R&D
Purification, Quality, Optimization

Services & R&D
Computational analyses: bioinformatics, statistics, machine learning, AI

Services & R&D
Services & R&D
Services & R&D
Banking system

Working cell banks & Master cell banks

Services & R&D
R&D programs only
Formulation and delivery systems

● Formulation : Live Biotherapeutic products, Drugs, inhaled products and aerosol therapies
Services & R&D
Services & R&D
Services & R&D
● Fermentation model to select relevant culture media, quality testing by flow cytometry
Services & R&D
● Delivery system (including inhaled produtcs)
Services & R&D
R&D programs only
Services & R&D
Galenic preparation for LBPs

Services & R&D
Pharmaceutical process development (drug substance, drug product) for LBPs

Services & R&D
R&D and preclinical batches

● Aerobic & anaerobic controlled conditions
Services & R&D
Services & R&D
● Quality testing – flow cytometry or NMR flow cytometry or NMR (viability, purity, bacterial load)
Services & R&D
cGMP manufacturing

Services & R&D
In silico prediction

Services & R&D
Microfluidic organs-on-chips - Microbiota-on-chip

Services & R&D
Specific ex vivo models

● Next-generation platforms for phenotypic screening, co-culture systems for human cells and microbes
Services & R&D
● Cell lines: Human bronchial epithelial cell lines, Vero 6
Services & R&D
Evaluate the pharmacology, toxicity of prophylactic and therapeutic candidates as well as pharmacomicrobiomic and toxicomicrobiomic interactions.

In vitro : Microfluidic, other in vitro models

Services & R&D
Services & R&D
Ex vivo : 3D models, Microfluidic organs-on-chips

Services & R&D
Services & R&D
In vivo models (rodent and non-rodent species)

Type of studies frequently performed:
• Exploratory pharmacology: PK/PD profiling
• Early tox studies
• Biodistribution studies (risks associated with Dose selection, dose regimen)
• Immunogenicity studies
• Impact of environmental factors
• Translocation, migration, infection

● Rodent (mice)
R&D programs only
Services & R&D
● Non-rodent (NHP)

The non-human primate model has several advantages for assessing candidates targeting infectious diseases. NHP is a relevant model to derisk leads before moving to the clinics
• Sensitivity to similar pathogens as humans
• Proximity of the immune system
• Close composition of microbiota
Services & R&D
Biological readouts

● Functional assays, ELISPOT, FACS, cytokines (MSD, ultrasensitive assays)...
Services & R&D
Services & R&D
Services & R&D
● Human immune repertoire and inflammatory biomarkers
Services & R&D
● Microneutralization assays (BSL 2/3)
R&D programs only
Services & R&D
● Histopathology, immunohistochemistry (for NHP)
Services & R&D
Preferential access to characterized human viral strains and other supply sources

In vitro models : human respiratory epithelium model, cell culture (Vero E6)

Services & R&D
Ex vivo models : organ on chip, microbiota on chip

Services & R&D
In vivo models (rodent and non-rodent species):

● Rodents models: Transgenic, axenic, gnotobiotic mice, Immunocompromised animal models
Services & R&D
R&D programs only
● Non-human primates: Infectious diseases NHP models (established or on-demand models), Microbiota transplanted NHP models
Services & R&D
Biological readouts

● Functional assays, Immunoassays, Molecular biology
Services & R&D
R&D programs only
Services & R&D
Services & R&D
Services & R&D
● Viral analysis (RT-qPCR, viral titration by TCID50), BSL 2/3
Services & R&D
● Microneutralization assays
Services & R&D
Microbiomics

“Multi-omics” approach for Microbiome profiling on different type of samples including complex samples (example: feces, …)

● Microbial sequencing (NGS short & long reads): Metagenomics (WGS, 16S, shotgun), single cell
Services & R&D
Services & R&D
Services & R&D
R&D programs only
● Metabolomics, Transcriptomics
Services & R&D
Flow cytometry for bacteria (aerobic/anaerobic)

Services & R&D
Biomolecular & Computational analyses

Services & R&D
Services & R&D
Services & R&D
Imaging (whole body, rodent)

R&D programs only
Explore host-microbiota, pharmacomicrobiomic interactions and how the microbiome influence health and disease.

In vitro/ex vivo assays for predictive response on targeted human microbiota

● Organ-on-a-chip
Services & R&D
● Next-generation platforms for phenotypic screening, co-culture systems for human cells and microbes
Services & R&D
● Human bronchial epithelium, Cell lines (Vero E6)
Services & R&D
R&D programs only
In vivo models (rodent and non-rodent species):

● Rodents: Transgenic, axenic, gnotobiotic mice, Immunocompromised animal models
Services & R&D
R&D programs only
● Non-human primates: Infectious diseases NHP models (established or on-demand models), Microbiota transplanted NHP models
Services & R&D
Biological readouts

● Functional assays, Immunoassays, Metabolic phenotyping, Molecular biology
Services & R&D
R&D programs only
R&D programs only
Services & R&D
Services & R&D
R&D programs only
● Human immune repertoire and inflammatory biomarkers
Services & R&D
● Viral analysis (RT-qPCR, viral titration by TCID50), BSL 2/3
Services & R&D
● Microneutralization assays
Services & R&D
Microbiomics

“Multi-omics” approach for Microbiome profiling on different type of samples including complex samples (example: feces, …)

● Microbial sequencing (NGS short & long reads)
Services & R&D
Services & R&D
Services & R&D
R&D programs only
● Metabolomics, Transcriptomics
Services & R&D
Flow cytometry for bacteria (aerobic/anaerobic)

Services & R&D
Biomolecular & Computational analyses

Services & R&D
Services & R&D
Services & R&D
Imaging (whole body, rodent)

R&D programs only
Towards the clinics: identify translational soluble, cell and microbiome-based clinical biomarkers

Current available biomarkers and discovery of novel biomarkers in different types of samples (blood, urine, faeces, tissues, microbiome biomarkers).

Method development & validation, testing

Services & R&D
Services & R&D
Highly specialized technological platform for soluble and cell biomarkers

Services & R&D
R&D programs only
R&D programs only
Omics platforms (including epigenetic)

Services & R&D
R&D programs only
Services & R&D
Services & R&D
R&D programs only
Metabolites

R&D programs only
Indirect biomarkers by imaging (MRI)

R&D programs only
Microbiomics

“Multi-omics” approach for Microbiome profiling on different type of samples including complex samples (example: feces, …)

● Microbial sequencing (NGS short & long reads): Metagenomics (WGS, 16S, shotgun), single cell
Services & R&D
Services & R&D
Services & R&D
R&D programs only
● Metabolomics, Transcriptomics
Services & R&D
Flow cytometry of bacteria (aerobic/anaerobic)

Services & R&D
Biomolecular & Computational analyses

Services & R&D
Services & R&D
Services & R&D
Big data analytics

Services & R&D
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