Technological, analytical and research based solutions

Explore the microbiome world with a network of experts! We support your projects with customized support, scientific and technical advice and high-value added services throughout the value chain of the development of therapeutic and prophylactic microbiome-based or drug candidates.

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Patient samples, biospecimens, Bacterial isolates

Services & R&D
R&D programs only
R&D programs only
R&D programs only
Services & R&D
Strain Identification (aerobic, anaerobic or GMO strains), targeted isolation

Services & R&D
Services & R&D
Strain biobank

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R&D programs only
Strain Characterization

● Genotyping, phenotyping
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R&D programs only
● Resistance and biochemical profiling
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● Metagenomic, Whole genome sequencing (WGS)
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Services & R&D
● Computational analyses
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Services & R&D
R&D programs only
Sorting & cultivation of microorganisms in controlled atmosphere

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Purification, Quality, Optimization

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Computational analyses: bioinformatics, statistics, machine learning, AI

Services & R&D
Services & R&D
Services & R&D
Banking system

● Working cell banks & Master cell banks
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R&D programs only
Formulation and delivery systems

● Formulation : Live Biotherapeutic products, Drugs
Services & R&D
Services & R&D
Services & R&D
● Fermentation model to select relevant culture media, quality testing by flow cytometry
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● Delivery system (including inhaled produtcs)
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R&D programs only
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Galenic preparation for LBPs

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Pharmaceutical process development (drug substance, drug product) for LBPs

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R&D and preclinical batches

● Aerobic & anaerobic controlled conditions
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Services & R&D
● Quality testing – flow cytometry or NMR flow cytometry or NMR (viability, purity, bacterial load)
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cGMP manufacturing

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Wet-lab and computational methods

Microbiomics

“Multi-omics” approach for Microbiome profiling on different type of samples including complex samples (example: feces, …)

● Microbial sequencing (NGS short & long reads): Metagenomics (WGS, 16S, shotgun), single cell
Services & R&D
Services & R&D
Services & R&D
R&D programs only
● Metabolomics, Transcriptomics
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● Connectomics
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Flow cytometry (aerobic/anaerobic)

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Biomolecular & Computational analyses

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Services & R&D
Services & R&D
Big data analytics

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In silico prediction

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Organ-on- a-chip / Microbiota-on-chip

● Gut brain axis
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● Other chips under development
Specialized ex vivo models

● Next-generation platforms for phenotypic screening, co-culture systems for human cells and microbes
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● Reconstructed nasal human airway epithelium
R&D programs only
Services & R&D
Innovative in vivo models

● Rodent models : Transgenic, axenic, gnotobiotic mice, Immunocompromised animal models
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R&D programs only
● Non-rodent models (Non-human primates) : microbiota transplanted models & infectious diseases models
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● Functional assays, Immunoassays, Molecular biology
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R&D programs only
R&D programs only
Services & R&D
Services & R&D
● Imaging (whole body, rodent & non-rodent), Indirect biomarkers (MRI)
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Biomarkers

Current available biomarkers and discovery of novel biomarkers in different types of samples (blood, urine, faeces, tissues, microbiome biomarkers)

● Method development & validation, testing
Services & R&D
Services & R&D
● Highly specialized technological platform for soluble and cell biomarkers
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● Omics platforms (including epigenetic)
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R&D programs only
Services & R&D
Services & R&D
R&D programs only
● Indirect biomarkers by imaging (MRI)
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R&D programs only
Explore host-microbiota interactions and how the microbiome influence health and disease?

In different therapeutic areas such as infectious and respiratory diseases, obesity and diet related pathologies, central nervous system, inflammatory diseases, …

Human microbiota biobanks

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R&D programs only
In vitro / ex vivo assays for predictive response on targeted human microbiota

● Organ-on-a-chip
Services & R&D
In vivo models (rodent / non-rodent)

● Rodent models: Transgenic, axenic, gnotobiotic mice, Immunocompromised animal models
Services & R&D
R&D programs only
● Non-rodent models (Non-human primates) : microbiota transplanted models & infectious diseases models
Services & R&D
Functional assays, Immunoassays, Immunophenotyping, Metabolic phenotyping, Molecular biology, Human immune repertoire and inflammatory biomarkers, Human sam

Services & R&D
R&D programs only
R&D programs only
R&D programs only
Services & R&D
Services & R&D
Services & R&D
Services & R&D
Imaging (whole body, rodent & non-rodent), Indirect biomarkers (MRI)

Services & R&D
R&D programs only
Towards the clinics: identify translational soluble, cell and microbiome-based clinical biomarkers (non-GLP and GLP)

Biomarkers: Method development & validation, testing

Services & R&D
Blood biomarkers, Cytokines, …

Services & R&D
R&D programs only
R&D programs only
Services & R&D
Metabolites

R&D programs only
RNA, DNA, epigenetics

Services & R&D
Services & R&D
Indirect biomarkers (inflammation, immune-system, metabolites, …)

Services & R&D
R&D programs only
Services & R&D
Services & R&D
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